WAVE Literature

WAVE Bioreactor Literature

Manuals | Protocols

Adenovirus | Baculovirus | Cell Therapy | Disposable Technology | Mammalian Cell Culture | Microbial | Microcarriers | Monoclonal Antibodies | Protein Production | Transient Transfection | Vaccines

Download current WAVE Bioreactor Manuals, Cell Culture Protocols, technical papers and other literature about the WAVE Bioreactor. Please contact us to receive copies of papers not available on-line. If you know of any publications using a WAVE system, that are not on this list, please let us know: WAVE.Info@ge.com


WAVE Bioreactor Manuals

Publication Title		Description		Click to Download
WAVE Bioreactor Technical Reference		Technical reference describes oxygen transfer and mixing capabilities along with example applications.		Technical_Reference.pdf
WAVE Bioreactor SYSTEM2/10EH operator's manual		Operator's Manual for 2/10EH for benchtop or incubator use.		SYSTEM210EH_Manual.pdf
WAVE Bioreactor SYSTEM20/50EHT operator's manual		Operator's Manual for electric unit. For benchtop use. Includes temperature control.		SYSTEM2050EHT_US_Rev_F.pdf
WAVE Bioreactor SYSTEM200EH operator's manual		Operator's Manual for 200 liter floor-standing unit.		SYSTEM200EHCE_Manual.pdf
WAVE Bioreactor SYSTEM500/1000EH operator's manual		Operator's Manual for 500 liter floor-standing unit.		SYSTEM5001000EHCE_Manual.pdf
WAVE Bioreactor Instrumentation Manual		Operator's Manual for WAVE Bioreactor instrumentation.		Instrument_Manual.pdf
WAVEPOD operator's manual		Operator's Manual for WAVEPOD.		Instrument_Manual.pdf
PCDAQ data acquisition		Operator's Manual for PC-based control and data logging software.		PCDAQ_Ver3.33_Manual.pdf
WB Supervisor Operator's Manual		Manual for WAVE Bioreactor supervisory control and data acquisition PC system.		SCADA_Ver3.33_Manual.pdf
DOOPT20 operator's manual		Operator's Manual for DOOPT20 dissolved oxygen amplifier.		DOOPT20_Manual.pdf
PUMP20 operator's manual		Operator's Manual for PUMP20 peristaltic feed/harvest pump.		PUMP20_Manual.pdf

WAVE Bioreactor Protocols

Publication Title		Description		Click to Download
PEI Transfection		PEI Transfection Protocol.		PEI_Transfection.pdf
Using Hillex microcarriers		Protocol for growing attachment-dependent cells on a polystyrene bead.		HillexMicrocarrier.pdf
Using Cultispher S microcarriers		Protocol for growing attachment-dependent cells on a macroporous gelatin microcarrier.		CultispherMicrocarrier.pdf
Using Fibra-Cel disks for attachment culture		Protocol for growing attachment-dependent cells on a polyester disk carrier.		Fibra-CelMicrocarrier.pdf
Using Cytodex 3 Microcarriers		Protocol for use of Cytodex 3 microcarriers.		Cytodex3Microcarrier.pdf
Growing Insect Sf9/Sf21 Cells		Protocols for growing and infecting insect cells. SYSTEM2/10 and SYSTEM20/50; SYSTEM200.		Insect210/2050.pdf Insect200.pdf
Growing NS0 Cells		Protocols for growing NS0 cells. SYSTEM2/10 and SYSTEM20/50; SYSTEM200.		NS0210/2050.pdf NS0200.pdf
Growing Insect High Five Cells		Protocols for growing and infecting High Five cells. SYSTEM2/10 and SYSTEM20/50; SYSTEM200.		HighFive210/2050.pdf HighFive200.pdf
Growing Mammalian Cells		Protocols for Chinese Hamster Ovary (CHO) Cells. SYSTEM2/10 and SYSTEM20/50; SYSTEM200.		CHO210/2050.pdf CHO200.pdf
Growing Hybridoma Cells		Protocols for Hybridoma cells. SYSTEM2/10 and SYSTEM20/50; SYSTEM200.		Hybridoma210/2050.pdf Hybridoma200.pdf
Perfusion Culture		Protocol for running perfusion culture.		Perfusion.pdf
Growing Yeast Cells		Protocol for growing yeast cells in suspension.		Yeast210/2050.pdf Yeast200.pdf
Growing HEK Cells		Protocols for Human Embryonic Kidney (HEK)293 Cells. SYSTEM2/10 and SYSTEM20/50; SYSTEM200.		HEK210/2050.pdf HEK200.pdf
Growing T Cells		Protocol for T-Cells. SYSTEM2/10 and SYSTEM20/50.		TCells210/2050.pdf
Growing Bacteria Cells		Protocols for E. Coli. SYSTEM2/10 and SYSTEM20/50; SYSTEM200.		Ecoli210/2050.pdf Ecoli200.pdf
Growing Plant Cells		Protocol for Plant Cells.		Plant.pdf

Adenovirus Publications and Technical Reports

Publication Title		Date Published		Category
Production of recombinant adeno-associated vectors using two bioreactor configurations at different scales J Virological Methods, Vol 145(2); 155-161		2007		Adenovirus
Adenovirus Production and Recovery using a WAVE Bioreactor SAIC- Frederick, NCI		2004		Adenovirus
Production of Adenoviral Vectors for Gene Therapy in Suspension Serum Free Cultures Presentation at Viral Vectors		2003		Adenovirus

Baculovirus Publications and Technical Reports

Publication Title		Date Published		Category
Production of selenomethionyl-derivatized proteins in baculovirus-infected insect cells Protein Science, Vol 16:2023-2029		2007		Baculovirus
Growing cholesterol-dependent NS0 myeloma cell line in the WAVE Bioreactor system: Overcoming cholesterol-polymer interaction by using pretreated polymer or inert fluorinated ethylene propylene. Presented at 2004 ACS. Printed Biotechnol Prog. 2005 Jul-Aug; 21 (4): 1341-6		2005		Baculovirus
Purification of Recombinant HIS-Tagged Viral proteins and evaluation of their sensitivity and specificity for detecting viral antibodies in Rodent Sera by ELISA - Feb 01 K. Dhawan Baculovirus Conference, 2001.		2001		Baculovirus

Cell Therapy Publications and Technical Reports

Publication Title		Date Published		Category
Considerations & Applied Solutions for Cell Therapy Product Development and Commercialization Progenitor Cell Therapy LLC; presented at symposium		2007		Cell Therapy
Personalized Cell-Based Medicine: Activated and Expanded T Cells for Adoptive Immunotherapy BioProcessing Journal, Vol 6, No. 2		2007		Cell Therapy
Lentiviral Vector Assists Gene Therapy GEN ENG NEWS, June 1, 2007		2007		Cell Therapy
Evolution of a Gene Therapy Company Introgen Therapeutics - presented at EU Antibodies & Recombinant - Barcelona, Spain		2006		Cell Therapy
GMP Production and Testing of Xcellerated T Cells for the Treatment of Patients with CLL Cytotherapy, Vol 6, No 6, pgs 554-562		2004		Cell Therapy
Comparison of a Static Process and a Bioreactor-based Process for the GMP Manufacture of Autologous Xcellerated T Cells for Clinical Trials Bioprocessing Journal, Vol 2, No 6 2003		2003		Cell Therapy

Disposable Technology Publications and Technical Reports

Publication Title		Date Published		Category
Tech Focus: Prognosticating the Future of the Bioreactor. Specific Demands Will Impact the Ongoing Evolution of this Device Genetic Engineering News, Jan 15 2008; Vol. 28, No. 2		2008		Disposable Technology
Whatever happened to ·.Smallpox? Discover Magazine		2007		Disposable Technology
Single-Use Technologies - A contract biomanufacturer's perspective BioPharm International, Suppl, Nov 2007		2007		Disposable Technology
WAVE Disposable Bioreactors - a pioneering technology BioPharm International, vol 20, no. 10		2007		Disposable Technology
CMOs Focused on Meeting Needs and Time Lines Genetic Engineering News, Oct 1, 2007; vol 27, no. 17		2007		Disposable Technology
Disposables crucial in future of patient-specific meds Pharma Technologist.com		2007		Disposable Technology
Demand Strong for Upstream Systems GEN ENG NEWS Vol 27, No 14		2007		Disposable Technology
"They Said it Wouldn't Work" India Today International		2006		Disposable Technology
Case Study of a Clinical-Scale CGMP Production Facility BioProcess International, Vol 4, No. 6 2006		2006		Disposable Technology
Bioprocessing Systems Go Disposable Chemical Engineering Progress, May 2006, Vol 102, No. 5		2006		Disposable Technology
Steel vs Bag: Comparison of Process Performance and Production Quality Amgen		2005		Disposable Technology
Disposable Bioreactors Become Standard Fare GEN ENG NEWS Vol 25, No 14		2005		Disposable Technology
Development of a Large-Scale Cell Bank in Cryobags for the Production of Biologics Merck Research - presented at CCE IX		2004		Disposable Technology
Validation of Bioreactors: Disposable vs. Reusable BioProcess International Industry Yearbook		2004		Disposable Technology

Mammalian Cell Culture Publications and Technical Reports

Publication Title		Date Published		Category
Establishment of a WAVE Bioreactor scale-down model for process development and characterization studies Bristol-Myers Squibb. ACS 2007 presentation		2007		Mammalian Cell Culture
Serum-Free Suspension Large-Scale Transient Transfection of CHO Cells in WAVE Bioreactors Molecular Biotechnology, Vol 34, Issue 2, pgs 191-200		2006		Mammalian Cell Culture
Evaluation of Disposable Bioreactors: Rapid Production of Recombinant Proteins By Several Animal Cell Lines - Oct 05 Bioprocess International Industry Yearbook, Vol 3, No. 9, October, 2005, pages 36-44.		2005		Mammalian Cell Culture
Characterisation and Operation of a Disposable Bioreactor as a Replacement for Conventional Steam In Place Inoculum Bioreactors for Mammalian Cell Culture Processes Lonza Biologics - presented at ACS		2002		Mammalian Cell Culture

Microbial Publications and Technical Reports

Publication Title		Date Published		Category
Evaluation of a novel WAVE Bioreactor(R) cellbag for aerobic yeast cultivation. Bioprocess Biosyst Eng. 2007 Mar 6		2007		Microbial

Microcarriers Publications and Technical Reports

Publication Title		Date Published		Category
Making Waves in Cell Therapy: The WAVE Bioreactor for the Generation of Adherent and Non-adherent Cells for Clinical Use Univ of Pennsylvania Abramson Cancer Inst.		2007		Microcarriers
Assessing a disposable bioreactor for attachment-dependent cell cultures Biopharm		2006		Microcarriers

Monoclonal Antibodies Publications and Technical Reports

Publication Title		Date Published		Category
Upstream processes in antibody production: Evaluation of critical parameters Biotechnol Adv Vol 1, 46-72		2008		Monoclonal Antibodies
Perfusion Culture of Hybridoma Cells for Hyperproduction of IgG(2a) Monoclonal Antibody in a WAVE Bioreactor-Perfusion Culture System Biotechnology Prog, 23(1):255-264		2007		Monoclonal Antibodies
Cholesterol Delivery to NS0 Cells: challenges and solutions in disposable linear low-density polyethylene-based bioreactors J Bioscience & Bioengineering, Vol 103, No. 1, pgs 50-59		2007		Monoclonal Antibodies
Using the Allergic Immune System to Target Breast Cancer: Production of Anti-MUC1 IgE Monoclonal Antibodies Presented at San Antonio Breast Cancer Symposium (December 14-17, 2006)		2006		Monoclonal Antibodies
The Use of Disposable Technologies in Antibody Manufacturing Processes Genentech		2005		Monoclonal Antibodies
On-line Purification of Monoclonal Antibodies Using an Integrated Stirred-Tank Reactor/Expanded-Bed Adsorption System Biotechnol. Progress, Vol 18		2002		Monoclonal Antibodies
Evaluation of DO and pH as key parameters for cell metabolic shift in the WAVE reactor MIT - presented at ACS		2002		Monoclonal Antibodies
Perfusion Culture in Disposable Bioreactors Genetic Engineering News, Vol 21, No. 7		2001		Monoclonal Antibodies
Disposable Bioreactor for Cell Culture Using Wave-Induced Agitation Cytotechnology, Vol 30, pgs 149-158		1999		Monoclonal Antibodies

Protein Production Publications and Technical Reports

Publication Title		Date Published		Category
Scalability of a Disposable Bioreactor from 25L - 500L Run in Perfusion Mode with a CHO-based Cell Line Bioprocessing Journal, Vol 3, No 4		2004		Protein Production
Semi-automated process for the factory-like production of recombinant proteins in the baculovirus system. Novartis - presented at Recombinant Protein Production meeting		2004		Protein Production
Optimisation of Protein Expression and Establishment of the WAVE Bioreactor for Baculovirus/Insect cell Culture Cytotechnology, Vol 38, pgs 77-85		2002		Protein Production
From Puddles to Waves: Journey to Consistency of Large Scale Expression Chiron		2002		Protein Production

Transient Transfection Publications and Technical Reports

Publication Title		Date Published		Category
The Happy Marriage of PEI and WAVE in Large-scale transient transfection Novartis Institute		2004		Transient Transfection

Vaccines Publications and Technical Reports

Publication Title		Date Published		Category
Establishment of a mink enteritis vaccine production process in stirred-tank reactor and WAVE Bioreactor microcarrier culture in 1-10 L scale Vaccine, Vol 25, Issue 20		2007		Vaccines
WAVE microcarrier cultivation of MDCK cells for influenza virus production in serum containing and serum-free media Vaccine, Vol 24, Issues 35-36		2006		Vaccines
Process Considerations for Cell-Based Influenza Vaccines Pharmaceutical Technology		2006		Vaccines

WAVE Mixer Literature

Download manuals, brochures, technical papers and other literature about the WAVE Mixer. Please contact us to receive copies of papers not available on-line. If you know of any publications using a WAVE system, that are not on this list, please let us know: WAVE.Info@ge.com

WAVE Mixer Manuals and Brochures

Publication Title		Description		Click to Download
Wave Mixer Catalog		Guide to selecting a Wave MIXER20/50 for your application and component catalog.		WaveMixer_catalog.pdf
Wave MIXER20/50EH Manual		Installation and operating manual.		MIXER2050EH_manual.pdf
Wave MIXER20/50P Manual		Installation and operating manual.		MIXER2050P_manual.pdf
Wave MIXER500/1000EH Manual		Installation and operating manual.		WAVEMIXER5001000EH_Manual.pdff

WAVE Mixer Publications and Technical Reports

Publication Title		Date Published
Bioprocessing Tutorial: Mixing in Large Disposable Containers - Feb '04 V. Singh, Genetic Engineering News, Feb 1, 2004.		2004
Bioprocessing Tutorial: Non-invasive Mixing in Bags - Feb '00 V. Singh, Genetic Engineering News, Feb 1, 2000.		2000

Sterile Tube Fuser Literature

Download technical papers and other literature about the Sterile Tube Fuser. Please contact us to receive copies of papers not available on-line. If you know of any publications using a WAVE system, that are not on this list, please let us know: WAVE.Info@ge.com

Sterile Tube Fuser Publications and Technical Reports

Publication Title		Description		Date Posted		Click to Download
Sterile Tube Fuser/ Hot Lips Tube Sealer Catalog		Catalog of Sterile Tube Fuser and Sealer options and accessories		Aug 08		WaveBrochure_Aug2008.pdf
Operation and Validation Guide		Function, design and validation basis of STF-IRc				Available through purchase of STF-IR CALKIT
Equipment Validation Protoco		Validation of STF-IRc				Available through purchase of STF-IR CALKIT

Hot Lips Tube Sealer Literature

Download technical papers and other literature about the Hot Lips Tube Sealer. Please contact us to receive copies of papers not available on-line. If you know of any publications using a WAVE system, that are not on this list, please let us know: WAVE.Info@ge.com

Hot Lips Tube Sealer Publications and Technical Reports

Publication Title		Description		Date Posted		Click to Download
Sterile Tube Fuser/ Hot Lips Tube Sealer Catalog		Catalog of Sterile Tube Fuser and Sealer options and accessories		Aug 08		WaveBrochure_Aug2008.pdf
Operation and Validation Guide		Describes the function, design, and validation basis of the Hot Lips Tube Sealer				Available through purchase of HLTS-CALKIT
Validation Protocol		Validation Protocol for Hot Lips Tube Sealer				Available through purchase of HLTS-CALKIT