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Downstream Bioprocessing of Monoclonal Antibodies (MAB1)
 Who should attend?
| Scientists and engineers looking for an introduction to process development methods for monoclonal antibody purification intended for biopharmaceutical applications |
| A basic understanding of chromatographic techniques is recommended, but not a prerequisite |
Course description
This four-day practical course begins with an introduction to monoclonal antibodies, antibody fragments and current challenges involved in biopharmaceutical production.
General purification strategies will be presented, focusing strongly on platform processes using affinity chromatography for capture. This will be followed by discussions on polishing steps, including multimodal techniques for key contaminants and bioburden removal.
In the practical session, you will define operating conditions for a human monoclonal antibody process; optimized for yield, productivity, and process economy.
Validation and regulatory concerns related to the purification process will also be addressed.
After the course, you will be able to:
| Communicate the usefulness of different techniques dependent on source material |
| Define a platform process for antibody purification suitable to the process objectives |
| Develop optimization methods and understand regulatory concerns unique to antibody manufacturing processes |
Course agenda, description & registration form
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* Register early to receive a discount:
| For 2008, receive discount for registration 30 days prior to course date. |
| For 2009, receive discount for registration 60 days prior to course date. |
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