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Fluorescent labelling and staining, when combined with an appropriate imaging instrument, is a sensitive and quantitative method that is widely used in molecular biology and biochemistry laboratories for a variety of experimental, analytical, and quality control applications. From genomics to proteomics, commonly used techniques such as total nucleic acid and protein quantitation, Western, Northern, and Southern blotting, PCR product analysis, microarray analysis, and DNA sequencing can all benefit from the application of fluorescence detection. Fluorescence detection offers a number of important advantages over other methods.