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Protein Arrays - Introduction
Protein arrays will revolutionize differential protein profiling in drug discovery and disease management.
Protein arrays offer a solution to accurate protein profiling and analysis of complex samples, complementing existing technologies, and providing the vital connection between gene and protein expression research.
Amersham Biosciences are developing proprietary products and technologies for protein arrays. The first products to be launched are CyDye™ fluors for protein arrays - CyTM3 or Cy5 monofunctional dye in a format specifically designed to meet the requirements of the protein array researcher.
The potential of protein arrays
The ability to profile the differences between biological samples is of fundamental importance in biology. These differences may occur as a result of a disease, the effects of a drug treatment, or of environmental changes and have classically been studied at both the gene and protein level using DNA microarrays and two-dimensional fluorescence difference gel electrophoresis (2-D DIGE) technologies, respectively.
Unlike the genome, the proteome varies constantly with the state and nature of the cell, making proteomics much more complex than genomics. There is therefore a need for more sensitive, high-throughput technologies for protein detection, quantitation, and differential expression analysis.
Protein arrays are emerging as a technology with the potential to fulfil the requirement for the sensitive and high-throughput screening of differential protein expression profiles.
Protein arrays in disease profiling and drug discovery
Protein arrays are already used in disease profiling, where differential expression of specific proteins is measured and correlated to a particular disease state or drug treatment.
Protein arrays can be used in many stages of the drug discovery process, including target identification and validation, toxicology, pathway elucidation, mode of action, and to look at drug resistance and surrogate markers of drug response.
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Documentation
Cy3 Mono-Reactive Dye Protein Array Grade Instruction
Cy5 Mono-Reactive Dye Protein Array Grade Instruction
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