What are kinases?
Human protein kinases are the largest superfamily of homologous proteins known to date and are involved in numerous and diverse cellular pathways. In mammalian kinases, two main subdivisions exist based on substrate specificity; Protein Tyrosine kinases (PTKs) and Serine/Threonine Protein kinases (S/T Ks) with short amino acid stretches characterizing each class. Each class can be further divided into sub-classes and subfamilies. Protein kinases enzymes play a significant role in the control many of the key steps in cellular processes, such as signal transduction and cell cycle control. The precise control of protein phosphorylation is fundamental to normal cellular behaviour. Uncontrolled signaling by kinases has been implicated in disease states such as cancer, athersclerosis, psoriasis and in inflammatory responses such as septic shock. For these reasons, inhibitors that block the activity of protein kinases and phosphatases are potentially useful for the development of therapeutic agents.
Not sure where to start? Consult the in vitro product selection guide to select the best product for your kinases in vitro application studies.
Not sure where to start? Consult the in vivo product selection guide to select the best product for your kinases in vitro application studies.
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