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GPCR & Regulators
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Product Selection Guide
Receptor Binding
GTPgS assay
CyDye reagents
Receptor Internalization
Second Messengers
Customization Possibilities
Recommended Equipment
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Products for receptor binding


Receptor binding assays involve the binding of a ligand to a specific receptor that is usually supplied in a membrane preparation. The ligand is generally labeled with a radioactive isotope when using Scintillation Proximity Assays (SPA) for example, or a fluorescent moiety when measuring assays such as fluorescence polarization.

GE Healthcare provides a wide range of radioactive ligands, assays and fluorescent products to address GPCR ligand binding and enable flexibility of choice

Assays:

GTPgS assay - Identify inhibitors of ligands that are active at G protein-coupled receptors and is fully amenable to automation for high-throughput screening.

Radiometric Imaging Beads - CCD Imagers

SPA Imaging beads are microspheres containing scintillant which emit light in the red region of the visible spectrum. As a result, these beads are ideally suited to use with a CCD imager
..Select-a-bead kit
Anti-Mouse
Anti-Rabbit
Membrane Binding Beads
Nickel Chelate (His-Tag)
Polyethyleneimine (PEI)
Polylysine
Protein A
Streptavidin
Wheat Germ Agglutinin
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Radiometric Imaging Beads - General research

SPA Scintillation beads are microspheres containing scintillant which emit light in the blue region of the visible spectrum. As a result, these beads are ideally suited to use with photomultiplier tube (PMT) counters such as the TopCount™ or MicroBeta™.
..Select-a-bead kit
Anti-Rabbit
Anti-Sheep
Arginine Binding YSi
Copper Chelate (His-Tag)
Glutathionine
Polyethyleneimine (PEI)
Polylysine
Protein A
Streptavidin
Wheat Germ Agglutinin (WGA)
....
Receptor Ligands >

A comprehensive range of radiolabeled and fluorescent ligands for novel and existing receptor subtypes. Through collaborations and licensing agreements around the world our Ligand Service seeks to offer the best ligand for each receptor subtype.
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Fluorescent screening reagents >

CyDye™ fluorophores are a popular choice for labeling in a variety of fluorescence based applications including drug screening and assay development. They are available in different chemistries to allow labeling via amine or thiol groups.
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Time resolved fluorescence >

CyDye fluorophores enhanced for TRF applications
TRF and CyDye generic reagents (acceptors)
TRF and CyDye generic reagents (donors)
TRF chelate labeling reagent




New to GPCR? Get started with the basics.

Consult the product selection guide to select the best product for your GPCR application studies.

See how we can create custom solutions for your specific needs.