Tip!
To find a specific word quickly in this list, please push "Ctrl" and "F" on your keyboard.
Type in the keyword you want in the "Find what:" field in "Find" window.
Push "Find next".
Growth-hormone secretagogues (GHSs) are small synthetic molecules that stimulate the release of growth hormone (GH) from the pituitary gland via a G-protein coupled receptor, GHS-R. Ghrelin is a ...
Lipid Kinases are enzymes that catalyze the phosphorylation of lipids within cells. They play an important role in many different physiological processes and serve as valuable drug targets. However, ...
The costs associated with increasing screen sizes can be controlled by reducing reagent usage, and increasing instrument throughput. For homogenous radiometric assays such as the scintillation ...
A 384-well radiometric signal increase protein kinase assay has been screened using either conventional Scintillation Proximity Assay (SPA) beads counted on a Packard TopCount or red shifted imaging ...
Cyclic AMP (cAMP), the introcellular second messenger, is involved in several important biological processes. The measurement of cAMP in whole cell level is useful in drug discovery as it reflects ...
MC4 (melanocortin, subtype 4) receptors have been linked in several studies to the central regulation of appetite. Evidence for the role of MC4 receptors in the central control of feeding comes from ...
a1-acid glycoprotein (AGP) and human serum albumin (HSA) are the most important drug binding proteins present in human plasma. HSA is considered to be largely responsible for the binding of acidic ...
Motilin is an endogenous 22 amino acid gastrointestinal peptide hormone expressed in the GI tract of humans and other species. [125I] Motilin should prove to be a valuable tool both in understanding ...
The benefit of fast read times using the Charged Coupled Device (CCD)-based LEADseeker Homogeneous Imaging System for measuring radiometric proximity assays in high density microplates has been well ...
LEADseeker homogeneous imaging system is a CCD camera-based instrument, combining imaging instrumentation and software with scintillant-containing beads for use with radiometric proximity imaging ...
Scintillation Proximity Assay (SPA) is a robust, versatile and sensitive homogeneous screening technology. Traditionally, screening assays based upon SPA have been performed in 96- well microplates. ...
Human serum albumin (HSA) is the most important carrier for acidic drugs in human plasma and has been shown to bind a large number of different compounds in a reversible manner. Several different ...
The Amersham Biosciences LEADseeker homogeneous imaging system has been designed for automated high throughput screening of radiometric, fluorescent and luminescent assays. LEADseeker incorporates a ...
LEADseeker homogeneous imaging system is a CCD camera-based instrument, combining imaging instrumentation and software with scintillant-containing beads for use with radiometric proximity imaging ...
A screening assay has been developed for a lipase enzyme using the Scintillation Proximity Assay (SPA) technology and LEADseeker Homogeneous Imaging System. The assay uses a novel [3H] labelled ...
LEADseeker Homogeneous Imaging System is a CCD camera-based instrument which combines imaging instrumentation and software with scintillant-containing beads that can be used in radiometric proximity ...
Early T-cell receptor mediated signal transduction involves the activation of several protein tyrosine kinases. The most fully characterized of these early-acting tyrosine kinases, p56lck, is ...
LEADseeker Homogeneous Imaging System is a CCD camera-based instrument which combines imaging instrumentation and software with scintillant-containing beads that can be used in radiometric proximity ...
The move towards ultra high throughput scintillation proximity assays (SPA) has increased the pressure on conventional plate counting technology and reagents. As plates have increased in well ...
High throughput screening of scintillation proximity assays (SPA) has necessitated the development of both reagents and alternative methods of detection from conventional scintillation counters. ...
G protein coupled receptors represent an important target class in drug discovery and the identifi cation of agonists and antagonists are continuously being
explored for various therapeutic ...