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Comparison of Human Ghrelin Receptor Binding Assays Using SPA and the LEADseeker Multimodality Imaging System (Scientific Poster 143)

Growth-hormone secretagogues (GHSs) are small synthetic molecules that stimulate the release of growth hormone (GH) from the pituitary gland via a G-protein coupled receptor, GHS-R. Ghrelin is a ...

Assay Development for Lipid Kinases Using LEADseeker Imaging Beads (Scientific Poster 132)

Lipid Kinases are enzymes that catalyze the phosphorylation of lipids within cells. They play an important role in many different physiological processes and serve as valuable drug targets. However, ...

Effective miniaturization of radiometric HTS assays using LEADseeker (Scientific Poster 114)

The costs associated with increasing screen sizes can be controlled by reducing reagent usage, and increasing instrument throughput. For homogenous radiometric assays such as the scintillation ...

Benefits from using imaging based detection (LEADseeker) and red-shifted emission for radiometric proximity assay screening (Scientific Poster 106)

A 384-well radiometric signal increase protein kinase assay has been screened using either conventional Scintillation Proximity Assay (SPA) beads counted on a Packard TopCount or red shifted imaging ...

Development of a homogenous whole cell cAMP assay using the LEADseeker (Scientific Poster 98)

Cyclic AMP (cAMP), the introcellular second messenger, is involved in several important biological processes. The measurement of cAMP in whole cell level is useful in drug discovery as it reflects ...

Miniaturisation of MC4 receptor binding assay to 384 and 1536 well microplate formats utilising SPA and LEADseeker technologies (Scientific Poster 97)

MC4 (melanocortin, subtype 4) receptors have been linked in several studies to the central regulation of appetite. Evidence for the role of MC4 receptors in the central control of feeding comes from ...

A High Throughput Screening Assay for Human a1-acid Glycoprotein Binding using SPA and LEADseeker Technologies (Scientific Poster 96)

a1-acid glycoprotein (AGP) and human serum albumin (HSA) are the most important drug binding proteins present in human plasma. HSA is considered to be largely responsible for the binding of acidic ...

The Development and Miniaturization of a SPA Motilin Receptor Binding Assay (Scientific Poster 95)

Motilin is an endogenous 22 amino acid gastrointestinal peptide hormone expressed in the GI tract of humans and other species. [125I] Motilin should prove to be a valuable tool both in understanding ...

An Evaluation of Instrument Performance using the LEADseeker Homogenous Imaging System as a Radiometric Assay Detector (Scientific Poster 91)

The benefit of fast read times using the Charged Coupled Device (CCD)-based LEADseeker Homogeneous Imaging System for measuring radiometric proximity assays in high density microplates has been well ...

A LEADseeker Imaging Assay For Measuring Cytochrome P450 Drug Interactions (Scientific Poster 78)

LEADseeker homogeneous imaging system is a CCD camera-based instrument, combining imaging instrumentation and software with scintillant-containing beads for use with radiometric proximity imaging ...

Miniaturization of the Phosphodiesterase SPA assay (Scientific Poster 71)

Scintillation Proximity Assay (SPA) is a robust, versatile and sensitive homogeneous screening technology. Traditionally, screening assays based upon SPA have been performed in 96- well microplates. ...

Miniaturization Of A Human Serum Albumin Binding Assay Using LEADseeker Homogenous Imaging System (Scientific Poster 67)

Human serum albumin (HSA) is the most important carrier for acidic drugs in human plasma and has been shown to bind a large number of different compounds in a reversible manner. Several different ...

Automating LEADseeker Proximity Assays (Scientific Poster 66)

The Amersham Biosciences LEADseeker homogeneous imaging system has been designed for automated high throughput screening of radiometric, fluorescent and luminescent assays. LEADseeker incorporates a ...

Measuring CYP3A4 and CYP2D6 Interactions using the LEADseeker Homogeneous Imaging System (Scientific Poster 65)

LEADseeker homogeneous imaging system is a CCD camera-based instrument, combining imaging instrumentation and software with scintillant-containing beads for use with radiometric proximity imaging ...

Development Of A Screening Assay For A Lipase Using Scintillation And Imaging Proximity Assay Technologies (Scientific Poster 56)

A screening assay has been developed for a lipase enzyme using the Scintillation Proximity Assay (SPA) technology and LEADseeker Homogeneous Imaging System. The assay uses a novel [3H] labelled ...

Detection Of 1536-Well Format Radiometric Proximity Assays With The New High Sensitivity LEADseeker Homogeneous Imaging System (Scientific Poster 53)

LEADseeker Homogeneous Imaging System is a CCD camera-based instrument which combines imaging instrumentation and software with scintillant-containing beads that can be used in radiometric proximity ...

Detection Of p56lck Kinase Activity Using SPA In 384-Well Format And Imaging Proximity Assays In 384 And 1536-Well Format (Scientific Poster 42)

Early T-cell receptor mediated signal transduction involves the activation of several protein tyrosine kinases. The most fully characterized of these early-acting tyrosine kinases, p56lck, is ...

Detection Of 1536-Well Format Radiometric Proximity Assays With The High Sensitivity LEADseeker Homogeneous Imaging System (Scientific Poster 41)

The LEADseeker Homogeneous Imaging System (Scientific Poster 38)

The move towards ultra high throughput scintillation proximity assays (SPA) has increased the pressure on conventional plate counting technology and reagents. As plates have increased in well ...

Application Of The LEADseeker Homogeneous Imaging System To The Detection And Quantification Of Miniaturised Proximity Assays (Scientific Poster 34)

High throughput screening of scintillation proximity assays (SPA) has necessitated the development of both reagents and alternative methods of detection from conventional scintillation counters. ...

Development of a Robust LEADseeker SPA Screen for a Neurotransmitter Receptor

G protein coupled receptors represent an important target class in drug discovery and the identifi cation of agonists and antagonists are continuously being explored for various therapeutic ...

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