GE Healthcare Life Sciences - Luminescence Posters

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Comparison of Serine/Threonine Protein Kinase Assays Using the LEADseeker Multimodality Imaging System (Scientific Poster 168)

Protein kinases are ideal drug targets for therapeutic intervention since they are involved in numerous signaling pathways that are known to contribute to human diseases including cancer, diabetes, ...

Development of a Microarrayed Compound Screening (µARCS) Format for the Identification of G-Protein-Coupled Receptor Agonists Using Aequorin (Scientific Poster 164)

G-protein-coupled receptors (GPCRs) are the targets of a significant number of currently marketed compounds, and therefore assays for the evaluation of GPCR-ligand interactions are critical for the ...

Development of 384 Well Microtitre Plate Based Luminescent Imaging Assays (Scientific poster 135)

Modern CCD equipment is capable of imaging a standard microtitre plate in one short exposure. This can drastically reduce the time required to quantitate all 384 wells in a plate compared to ...

Luciferase reporter gene assays on the LEADseeker Homogeneous Imaging System (Scientific Poster 100)

As G-protein coupled receptors (GPCRs) constitute targets for >70% of drugs in current use, a large proportion of high throughput drug screening (HTS) is conducted on this type of receptor. Several ...

Optimization of LEADseeker for the Measurement of Luminescence (Scientific Poster 84)

Imaging systems are seeing increasing use in High-Throughput Screening (HTS) in the support of drug discovery. The pioneering LEADseeker Homogeneous Imager has delivered assays using both radiometric ...

Cell Based Luciferase Reporter Assays for the LEADseeker Homogeneous Imaging System (Scientific Poster 72)

The consequences of specific signal transduction events are frequently assessed by reporter genes. Reporter genes typically consist of a combination of specific transcription factor binding sites and ...

Design And Synthesis Of Probes For Next Generation Luminescence Detection Platforms (Scientific Poster 59)

Since the serendipitous discovery of the first cyanine dye in the mid-nineteenth century many hundreds of variations have been prepared, primarily as sensitisers for emulsion-based photographic film. ...

In Vivo and In Vitro Luminescence Assays as Measured on LEADseeker (Scientific Poster 54)

A novel imaging system, suitable for high throughput screening (HTS) applications, has been developed by Amersham Biosciences. The system uses a cooled CCD camera with a telecentric lens, for imaging ...

In Vivo and In Vitro Luminescence Assays as Measured on LEADseeker (Scientific Poster 48)