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Comparison of Serine/Threonine Protein Kinase Assays Using the LEADseeker Multimodality Imaging System (Scientific Poster 168)

Protein kinases are ideal drug targets for therapeutic intervention since they are involved in numerous signaling pathways that are known to contribute to human diseases including cancer, diabetes, ...

Demonstration and Automated Handling of a Miniaturized, 1536-well, MMP-3 FRET Protease Assay Screen using Imaging and a Model Compound Set (Scientific Poster 159)

Matrix metalloproteinases (MMPs), play a central role in the timely breakdown of extracellular matrix. This is essential for processes such as embryonic development, morphogenesis, tissue resorption ...

The Evaluation of Cyclic AMP Assays on the LEADseeker Multimodality Imaging System (Scientific Poster 139)

Cyclic AMP (cAMP) is an important second messenger involved in the regulation of many biological processes. Identifying novel drugs or agonists, which modulate its production, is therefore key to ...

Development of 384 Well Microtitre Plate Based Fluorescent Imaging Assays for Cytochrome P450s and Caspases (Scientific poster 134)

Modern CCD equipment is capable of imaging a standard microtitre plate in one short exposure. This can drastically reduce the time required to quantitate all 384 wells in a plate compared to ...

Homogeneous Binding Assays using the Time Resolved Fluorescence and Fluorescence Polarization Modalities of a High Throughput Imaging System (Scientific Poster 123)

Homogeneous Fluorescence Polarization (FP) assays have previously been reported for the binding of telenzepine to Chinese Hamster Ovary cells expressing the M1 muscarinic acetylcholine receptor. We ...

Improving MMP Activity Assays using Novel Peptide Substrates and a CCD-based Imaging Platform (Scientific Poster 104)

Matrix metalloproteinases (MMPs) are a family of structurally and functionally related enzymes which are involved in the normal, physiological turnover of extracellular matrix proteins. MMP activity ...

A Homogeneous Imaging Assay for Measuring the Activity of the Aspartic protease Cathepsin D Using a Fluorogenic Peptide Substrate (Scientific Poster 82)

Cathepsin D is one of the major lysosomal aspartyl proteases in almost all mammalian cells which degrades various substrates at an optimal pH of 3.5-5. This endopeptidase has been linked with various ...

Assaying MMP activity using Fluorogenic Substrates and a Fluorescent Imaging System (Scientific Poster 77)

Members of the matrix metalloproteinase (MMP) family play an important role in tissue remodeling and repair. However, inappropriate MMP activity has been implicated in a number of disease states ...

A Homogeneous Imaging Assay For DNA Helicase Activity Using A Quenched DNA Duplex Substrate (Scientific Poster 75)

DNA helicases are ubiquitous enzymes involved in almost all aspects of nucleic acid metabolism including DNA replication and repair. They couple the free energy of ATP hydrolysis to the unwinding of ...

Homogeneous Imaging Assay For Measuring Aspartic Protease Activity (Scientific Poster 74)

Cathepsin D is a lysosomal aspartic proteinase found in almost all mammalian cells. In addition to the normal physiological processing of intracellular proteins, cathepsin D has been implicated in a ...

Assay Of Acidic Aspartic Protease Activity Using pH Stable Fluorescent Probes And Fluorescence Imaging (Scientific Poster 68)

The LEADseeker programme from Amersham Biosciences combines CCD based imaging technology with a range of proprietary reagent toolboxes to support the development of homogeneous, miniaturised, ...

The Use Of Fluorescence Technologies To Measure Specific Signal Transduction Events And Molecular Interactions (Scientific Poster 64)

Signal transduction events and molecular interactions are popular targets for drug discovery by pharmaceutical companies. Radioactive methodologies are often employed; scintillation proximity asssay ...

A Fluorescence Imaging System to Examine Biomolecular Assays in High Throughput Screening (Scientific Poster 52)

The recent introduction of new fluorescent dyes with improved photophysical properties has made high throughput fluorescence assay technologies practicable. This advance in fluor properties has also ...

Homogeneous Enzyme Cleavage Assays Using FRET In A Fluorescent Imaging System (Scientific Poster 51)

The application of FRET (fluorescence resonance energy transfer) molecules used as substrates in enzyme assays has attracted much recent interest. Homogeneous enzyme cleavage assays using FRET in a ...

Homogeneous FRET Assays For The Detection Of Biomolecular Events In A Fluorescent Imaging System (Scientific Poster 50)

The drive for increased throughput within the drug discovery process has prompted a new phase of assay development combining miniaturisation with automation. In parallel, there has also been a ...

Improvements In Fluorescence Polarization Assay Performance And Development Of New Fluor Chemistries For The Same (Scientific Poster 49)

Fluorescence Anisotropy (FA) was first described in 1926. These investigations derived several equations, the principles of which have been adapted subsequently to describe the use of a Fluorescence ...

Investigations Into The Use Of Homogeneous FRET Assays And Fluorescence Imaging For HTS Applications (Scientific Poster 47)

Fluorescence resonance energy transfer (FRET) occurs between two neighbouring fluorophores when the emission spectrum of one (the donor) overlaps the excitation spectrum of the second (the acceptor). ...

High Technology Fluorescent Probes For Applications In Modern High Throughput Screening And Instrumentation (Scientific Poster 46)

Cyanine dyes were first synthesised in the mid 1800’s for the photographic industry as spectral sensitisers ordesensitisers for silver halide emulsion films. However, in recent years interest in ...

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