Analysis of the final compound
Our Analytical Science Group of highly experienced analytical scientists, who are dedicated to the analysis of custom labeled products. Using a wide range of modern analytical equipment installed in state of the art facilities we offer a broad range of chromatographic, spectroscopic and physical analysis techniques for the quantitative and qualitative analysis of carbon-14, tritium, iodine-125 and stable isotope labeled compounds. Copies of the chromatograms and spectra generated can be provided with radiolabeled final product upon request.
Chromatographic analysis
Liquid chromatography (LC), radiochemical purity and chemical purity can be determined for a wide range of products using reverse and normal phase, chiral and gel permeation chromatography techniques.
Gas chromatography (GC) Radiochemical purity and chemical purity can be determined for volatile samples using gas chromatography (GC).
View a sample Gas Chromatogram
Spectroscopic analysis
Mass spectroscopy (MS), specific activity or isotopic abundance can be determined by mass spectroscopy. Chemical identity can be confirmed either by comparison with a known marker or by LC/MS/MS and accurate mass analysis. An array of ionization methods are possible including electron impact (EI), chemical ionisation (CI), fast atom bombardment (FAB), electrospray (ESI) and atmospheric pressure chemical ionization (APcI). Some instruments have interfaces for coupling to liquid chromatography (LC) and gas chromatography (GC).
Nuclear magnetic resonance spectroscopy (NMR)
Molecular structure can be confirmed using nuclear magnetic resonance. It can also be used to monitor for the presence of solvents and impurities.
Other available techniques include:
Classical wet chemistry techniques, ion selective electrode, Karl Fischer, polarimetry
Documentation
A full analytical package is supplied with each preparation, which includes a radiochemical purity analysis by TLC or HPLC and where appropriate, a specific activity determination by mass spectroscopy. If required, we can provide detailed documentation on all aspects of the labeling project. This package includes:
- A product specification sheet with appropriate technical data
- Original analytical scans
Further documentation, including full synthetic write-ups can be provided on request and supply:
- As a signed bound copy
- As a signed loose copy
- In electronic format
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