 |
Biotrak Assays for Multiple Sclerosis
 |
| Categories of Mediators | Biotrak™ Assays |
| Demyelination of oligodendrocytes | TNFa, IL-1b, IL-6 |
| Stimulate astrocytes (responsible for scarring) | IL-1b, TNFa |
| Control of TNFα production by PDE enzymes | cAMP |
Control of lymphocyte trafficking
to inflammation sites | TNFa, TNFb, IL-1b,IL-2, IFNg, TGFb |
| Th1/Th2 cytokines | IL-4, IL-10, IL-12, IL-13, TGFb |
| Inflammatory mediators | PGE2, IL-6 |
| Chemokines - attract inflammatory cells to CNS | MCP-1 |
| Degrade basement membrane allowing cells to cross blood brain barrier | MMPs |
| Increased levels in CSF | LTB4, LTC4, MMP-9, IFN
g, TNFa, IL-6, IL-12 |
|
| |
| |
|
Demyelination of oligodendrocytes
Return to top
Stimulate astrocytes (responsible for scarring) IL-1β, TNFα
Return to top
Control of TNFα production by PDE enzymes
Return to top
Control of lymphocyte trafficking to inflammation sites
Return to top
Th1/Th2 cytokines
Return to top
Inflammatory mediators
Return to top
Chemokines - attract inflammatory cells to CNS
Return to top
Degrade basement membrane allowing cells to cross blood brain barrier
Return to top
Increased levels in CSF
Return to top |
|
Pack Leaflets
