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ÄKTAcrossflow - the intelligent membrane filtration system (Downstream 39, November 2005)

ÄKTAcrossflow™ is a fully automated filtration system for cross flow membrane screening and process development. It is also the first system to enable automation at small-scale, with capacity ranging ...

Butyl-S Sepharose 6 Fast Flow: purification or removal of highly hydrophobic biomolecules at low salt conditions (Downstream 39, November 2005)

Butyl-S Sepharose™ 6 Fast Flow is an ideal medium to use for either purification or removal when a sample contains strong hydrophobic biomolecules. It is the least hydrophobic medium in our ...

Gendicine - the first gene therapy product approved (Downstream 39, November 2005)

In October 2003, the recombinant Human Ad-p53 Injection, trademarked as Gendicine and developed independently by Sibiono successfully obtained a Drug license. At the beginning of 2004, Production ...

GlaxoSmithKline Biologicals takes delivery of its 50th BioProcess system (Downstream 33, 2001)

GlaxoSmithKline Biologicals in Belgium specializes in the development and production of human vaccines. The close communication between our two companies has lead to 50 BioProcess systems in ...

Large-scale production of IPV using custom designed chromatography columns (Downstream 35, September 2002)

Statens Serum Institut, Denmark has been producing Poliovirus Vaccine since the 1950s. STREAMLINE™ expanded bed adsorption was introduced into their process a few years ago. A recent switch to using ...

Purifying human influenza virus vaccine - towards a generic strategy

Viral vectors and viral vaccines play an important role in current medical approaches. Viral vectors like adenoviruses, adeno-associated viruses, or retro-viruses are the vehicles being developed for ...

Scale-up of a method for highly pure plasmid DNA (Downstream 38, 2004)

Gene therapy is the introduction of DNA into human cells to achieve some desired therapeutic effect. Delivery to cells can be done directly through vaccination or through utilizing viral vectors. ...

Viral clearance by chromatography: predicting optimal conditions and media lifespan (Downstream 39, November 2005)

The International Conference on Harmonization (ICH) guideline Q5A on viral clearance describes the concern that over time and with repeated use, the ability of chromatography columns to clear viruses ...